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A subsequent study that followed 43 patients for up to four years found those with mild dementia or moderate-early dementia who took lipoic acid (600 mg/day), in addition to acetylcholinesterase inhibitors, experienced slower cognitive decline compared to the typical cognitive decline of Alzheimers patients as reported in the literature (102)

Clinical trials have shown promising results, with many participants achieving significant weight loss and improvements in their health markers

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AMPK activation by metformin depends on liver kinase B1 (LKB1) and is essential for suppressing hepatic gluconeogenesis (Shaw et al., 2005)